New hearing for 2020

New you, new hearing for 2020

So the new year and new decade is here. As loud as the T.V. maybe you still are 100% sure you don’t need at the very least a hearing test. You are not that bothered that your granddaughters first few words are unheard by you or that the gossip from the next door neighbour just isn’t as good as it used to be. She talks so quietly these days you really are tired of straining to hear.

Maybe the Postman just didn’t push the doorbell hard enough as you were in when he called and you missed that package that you were waiting in all day for an now you have to go 14 mies to the sorting office with I.D. to make the collection.. At rush hour!

These little annoyances crammed with so many others it would take more than the internet to tell them all, maybe down to one thing? Your hearing maybe not as it once was (understatement possibly).

Hearing tests at the Keynsham hearing centre Bristol

Here at Keynsham Hearing we get to see many reluctant men and women who have for years put off what we all know. We are all getting older and really annoyingly we are hard of hearing! Or DEAF!

There we said it. Now we have that out there is usually a huge relief as it’s not as bad as you think. These days there is a huge difference in how hearing can be corrected in the main part. Tech is smaller, fancier and more connected than ever before.

We do understand the stigma attached to admitting that your hearing is not what it used to be. We also understand hearing is vital for people to stay connected with their family and daily lives.

Ear wax removal Keynsham Somerset

If you feel that you or someone you love could do with knowing just what their hearing is really like then we are happy to conduct a simple hearing tests and go from there. It may even by a simple ear wax issue that can be corrected in minutes.

The latest 2020 hearing aids available at the Keynsham hearing centre.

Book you appointment by calling or clicking here

January 4, 2020/by admin

Devon hearing centre, Hearing loss

New report in deafness therapy Devon

New report in deafness therapy has been reported by a new scientific paper. Here at the Honiton hearing centre are keen to keep up with the latest information to keep our patients informed.

Below is what was reported by the hearing review recently.

High-pressure Oxygen Therapy May Help Treat Sudden Deafness, Says ‘JAMA’ Study

Bottom Line: The addition of hyperbaric oxygen therapy (where patients receive pure oxygen in a pressurised chamber) to standard medical treatment was associated with an improved likelihood that patients who experience sudden deafness might recover all or some of their lost hearing, JAMA Network announced on its website. Sudden deafness, also known as sudden sensorineural hearing loss (SSNHL), is hearing loss that happens within a few days and often has no identifiable cause. This study combined the results of 19 studies, including three randomised clinical trials, and suggests a greater benefit of adding the hyperbaric oxygen therapy may be associated with those patients who have severe to profound hearing loss and who failed to recover after standard medical treatment. A limitation of this study is that because a substantial number of patients with SSNHL will spontaneously recover, the benefits of treatment may not have been accurately evaluated.

Devon hearing centre

Authors: Tae-Min Rhee, MD, DMO/UMO, National Maritime Medical Center, Changwon, Republic of Korea, and coauthors.

Original Paper: Rhee T-M, Hwang D, Lee J-S, Park J, Lee JM. Addition of hyperbaric oxygen therapy vs medical therapy alone for idiopathic sudden sensorineural hearing loss: A systematic review and meta-analysis. JAMA Otolaryngol Head Neck Surg. 2018. Available at: https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2704029

Source: JAMA Network, JAMA Otolaryngol Head Neck Surg

December 23, 2019/by admin

Devon hearing centre, News

Devon ear wax removal centre

Available at the Honiton hearing centre near Exeter

Ear wax removal doesn’t have to be a chore. We are a fully accredited ear wax removal specialist centre that covers the whole of Devon and Somerset, handily located in Honiton close to Exeter. We are a family run business and cherish that we serve our local community, also people from a far. We use the traditional ”Ear syringing” technique, which is actually called water irrigation and isn’t anything like a carry on film. You can watch Colin Eaton talk about ear syringing here in this video. He will explain in detail what that was all about and what is now the gold standard.

Devon Microsuction

The Gold standard these days is called Microsuction or Micro-Suction depending where you read. It is basically a very very small hoover type of device that gently sucks up the ear wax in a safer manor than hitting the ear with pressured water which they did in the bad old days. Ears are very delicate, with todays techniques the risk is a lot lower.

You can watch how Micro-Suction is performed by watching this video here conducted again by Colin Eaton who is the lead audiologist here at the Honiton hearing centre.

Devon ear wax removal centre

We look forward to seeing you if you haven’t been here before, if you could please call Sam on reception or you can make an online booking by clicking here.

October 9, 2019/by admin

Depression and hearing, Hearing aids

Depression and Hearing link

Depression and Hearing link, Somerset & Devon

Depression and Hearing link, Bristol. Stephen Neal audiologist who is based at the Keynsham hearing centre knows that Depression and hearing can be linked.

Depression and hearing link found by researchers.

New report into depression and hearing has been published. We at the Keynsham hearing centre are well aware of this link and can help with making your hearing a little better.

Somerset hearing and Ear wax removal centre

Somerset and Devon hearing and Ear wax removal centre are at the Keynsham hearing centre and the Honiton hearing centre. These are independent hearing and ear wax specialist covering Bath, Bristol, & Somerset and Devon. If you are having issues with hearing in general we can conduct a hearing test at Keynsham or Honiton. The comprehensive hearing test will take around an hour of your time, but the results will be know there and then putting you in control of your hearing. We can then discuss what hearing instrument (hearing aid) you may need if required. There could be other issues at play if you are not hearing as well as you think you should be. We can before the test look to see if you have any ear wax present. Ear wax isn’t usually an issue, we all need a little for good ear health. However in some cases excessive ear wax build up can become an issue and if you have excessive ear wax we will clear this before any test is conducted.

Depression and Hearing link, Somerset and Devon

Ear wax removal is very easy and painless. We use the Microsuction ear wax removal method as this really is the gold standard of ear wax removal. We also can use the older method of ear wax removal called irrigation or some may know this as ear syringing. This method uses warm water to gently irrigate the ear to help release the ear wax out from the ear.

You can watch our ear wax removal here

So if you are having some hearing issues and would like afamily run professional ear wax removal service then book an appointment. We can discuss at the appointment any of the issues at length. After all we are all ears!

Ear wax removal Somerset and Devon

Ear wax removal.co.uk/ News:

Bringing world wide news on hearing to our local area.

Study Shows Older Adults with Hearing Loss at Higher Risk for Depression

Chalfont hearing centre

The results of a study investigating the connection between hearing loss and depression found that older adults with some form of hearing loss were 47% more likely to also have depression symptoms, according to an article in Reuters.

East Devon Hearing centre

Originally published in The Gerontologist, the research reviewlooked at 35 previous studies encompassing 147, 148 participants, who were at least 60 years old.

“We know that older adults with hearing loss often withdraw from social occasions, like family events because they have trouble understanding others in noisy situations, which can lead to emotional and social loneliness,” lead study author Blake Lawrence of the Ear Science Institute Australia, in Subiaco, and the University of Western Australia in Crawley, was quoted as saying in Reuters.

Additionally, the article goes on to add that the brain may work harder to interpret sound from a weaker auditory signal, draining resources needed to maintain working memory or other cognitive functions. A weaker signal may also cause the “reorganization” of neural pathways, potentially changing the way depression is regulated in the brain.

Ear syringing Devon

In a new white paper produced by The Hearing Review and sponsored by Hamilton CapTel, “Depression, Hearing Loss, and Treatment with Hearing Aids,” audiologist and educator Victor Bray, PhD, reviews previous landmark studies as well as more recent research into the complex relationship between hearing loss and depression. The paper helps identify patient populations who might benefit most from hearing devices. Additionally, Dr Bray’s webinar “Depression, Hearing Loss, and Treatment with Hearing Aids,” discusses the risk factors for depression among people with hearing loss as well as why hearing care providers should screen for depression when risk factors are present.

Original Paper: Lawrence BJ, Jayakody DMP, Bennett RJ, Eikelboom RH, Gasson N, Friedland PL. Hearing loss and depression in older adults: a systematic review and meta-analysis. The Gerontologist. 2019:1-19. DOI: https://doi.org/10.1093/geront/gnz009

Source: Reuters, The Hearing Review, The Gerontologist

April 30, 2019/by admin

Earwax removal, Hearing aids

Hearing aids for Devon and Somerset

Hearing aids for Bristol and Bath by Stephen Neal. Stephen prides himself on being at the vanguard of hearing technology. Based at the Keynsham hearing Centre, Stephen Neal is a lead audiologist and is first class at keeping up with the new tech that comes out constantly. Today we he is looking at the recently announced Phonak Marvel. For those who don’t know what this product is here is a sample from their Press release.

”In October 2018, Phonak introduced Marvel, a hearing aid family that’s said to “combine all the top-requested features from hearing aid wearers” into one solution.

Hearing aids for Devon and Somerset

According to Phonak, this technology also helps to improves accessibility to hearing care by empowering consumers to benefit from a suite of smart apps that connect hearing aid wearers with their hearing care professional via smartphone. These include video chat, instant feedback regarding their wearing experience, remote fine-tuning from anywhere in the world, and real-time, voice-to-text transcription of phone calls”.

Hearing aids Honiton, Devon

Sounds good? We think so and we are pleased that Phonak has won a prestigious award saying that they agree too. If this Phonak product sounds like something you may like more info on then please let us know and we could arrange an appointment to see if this would be right for you.

See the rest of the info on the Phonak Marvel product bellow.

Check out our earwax removal video here.

Earwax removal News:

Phonak Marvel Wins Silver Edison Award for Hearing Aid Design Technology

Phonak Marvel available at the Honiton hearing centre Devon

Phonak Marvel, said to be “the world’s first hearing aid” to combine clear sound quality with universal “made for all” Bluetooth connectivity, received a Silver Award in the hearing aid design technology category at the Edison Awards gala in New York City, the hearing aid manufacturer announced. The Edison Awards, named after Thomas Alva Edison, recognizes and honors innovators and innovations.

In October 2018, Phonak introduced Marvel, a hearing aid family that’s said to “combine all the top-requested features from hearing aid wearers” into one solution.

Ear wax removal Devon

According to Phonak, this technology also helps to improves accessibility to hearing care by empowering consumers to benefit from a suite of smart apps that connect hearing aid wearers with their hearing care professional via smartphone. These include video chat, instant feedback regarding their wearing experience, remote fine-tuning from anywhere in the world, and real-time, voice-to-text transcription of phone calls.

All nominations were reviewed by the Edison Awards Steering Committee and the final ballot sent to an independent judging panel. The judging panel was comprised of more than 3,000 professionals from the fields of product development, design, engineering, science, marketing, and education, including professional organizations representing a wide variety of industries and disciplines.

Hearing aids for Devon and Somerset

For more information on the 2019 Edison Awards, please visit: www.edisonawards.com. Applications for the 2020 awards will open in August 2019.

Source: Phonak, Edison Awards

Images: Phonak

April 23, 2019/by admin

Earwax removal

Ear wax removal Devon and Somerset

Ear wax removal Devon and Somerset is available at the Honiton hearing centre and the Keynsham hearing centre. If you are suffering from excessive wax build up in the ear or ears we can come to your aid. Using Micro-Suction or the traditional irrigation technique, (some call it ear syringing), it only take a few mins to painlessly remove excess ear wax. Please click here to see how Micro-Suction works via our new online video on the Honiton Hearing website.

To see how ear wax removal at the Keynsham centre please click here.

If you live in Tiverton area then contact us for Ear wax removal near Tiverton Devon

Honiton hearing centre also conduct lots of other ear related issues such as hearing tests, dispensing the very latest digital hearing aids along with hearing aid servicing and setting up of new hearing aids after you purchase them. If you need any of our services please book in using our online booking calendar or call Sam on reception.

Honiton & Keynsham news:

Philips Hearing Aids Introduced by Demant

Published on April 10, 2019 by The hearing review .com

Honiton hearing Devon

Demant, Copenhagen, Denmark, has announced the introduction of Philips branded hearing aids to the global hearing aid market, according to a press release from the company. A new player, the Philips brand is entering the hearing healthcare market with a complete range of premium hearing aids, accessories, and applications to best serve hearing aid users. Demant states Philips Hearing Solutions will quickly become a trusted brand with hearing care providers and users, as it has great potential around the world to present unique opportunities for hearing care professionals in an ever-evolving market.

Ear wax removal Devon and Somerset

In August, Demant announced a licensing agreement with Philips, which is headquartered in Eindhoven, The Netherlands, to bring Philips-branded solutions to the hearing healthcare market. Demant (formerly William Demant Holding) is the parent group of Oticon, Sonic, and Bernafon hearing aids, as well as Oticon Medical.

Ear wax removal near Tiverton Devon

“Based on a shared vision of improving the lives of people through innovative healthcare this new cooperation will not only change the way we see hearing healthcare, but also widen the definition of hearing healthcare, supporting healthier lifestyles and active aging,” said Spencer Ramsey, Senior Director of Brand Licensing, Philips, in the press statement. “Combining Demant’s world-leading hearing aid technology with Philips’ global brand presence in healthcare, the cooperation will enrich the hearing healthcare experience.”

The new premium Philips hearing aids—named Philips HearLink—are now available for hearing care professionals in selected countries. The look and feel of the Philips HearLink hearing aids is designed to cater to today’s baby boomer generation with design and usability developed for this expanding market. Philips HearLink users will benefit from connectivity between their hearing aids and the devices they use in their everyday life, such as smartphones and televisions. The hearing aids will reportedly be manufactured by Demant using the Velox-S and Velox platforms, and will be available in a complete range of styles, including RICs, BTEs, ITCs, CICs, and IITs.

Søren Nielsen

“The Philips hearing aids will provide users with an innovative, future-proof hearing solution,” says Demant President & CEO Søren Nielsen. “We live in an age where user engagement and digital services are shaping the future of healthcare technology. More and more people are conscious of taking control of their own personal healthcare and are using electronic devices to do so. In this light, Philips Hearing Solutions offers new and exciting premium solutions alongside Philips’ healthcare ecosytem, which will attract interest and generate significant benefits to users, ultimately supporting our valued customer base of hearing care professionals.

Bath ear wax removal at the Keynsham Hearing centre

“With this partnership, we take connected hearing healthcare to the next level and offer new and exciting solutions within integrated healthcare services to the benefit of both professionals and people suffering from a hearing loss,” continued Nielsen. “Health, caring, and innovation are cornerstones in the vision of both Demant and Philips, which makes the partnership a great match for the future. Furthermore, it will strengthen and add value to both companies’ ambition to improve people’s lives.”

The Philips brand is something of a “back to the future moment” for more seasoned dispensing professionals. Philips was a well-known hearing aid brand in the 1990s, and the company embarked on a technical collaboration with Telex then exited the market just before the turn of the new century when Beltone purchased Philips’ hearing aid technology. The Hearing Review published numerous news and technical articles about Philips technology in the 90s.

Traditionally, hearing aid branding has not played a large role in hearing healthcare; MarkeTrak 9 suggested that less than half of hearing aid users (43%) could identify the brand of their device. However, many experts in the industry believe this is due to change, as more consumers are expected to enter the market and there is continued competition and aggressive marketing among dispensing chains, pharmacies, mass merchandisers, and online retailers. The Philips brand brings with it one of the world’s best known and trusted healthcare and consumer electronics brands.

For further information about Philips Hearing Solutions and a full presentation of the Philips HearLink product range, visit: hearingsolutions.philips.com

April 16, 2019/by admin

Hearing aids

Latest digital hearing aids, Devon and Somerset

New hearing aids in Devon and Somerset at the Honiton hearing centre and Keynsham, hearing centres. We are used to new hearing aids arriving from various manufacturers all year round, but when something is really new and exciting we love to tell you and our existing clients why we are so excited.

Hearing aids have evolved in recent years. Digital hearing aids have made the devices so small and powerful they are no longer what people expect to see. The huge hearing aid of old is getting less visible these days, the new as powerful hearing aids are now tiny. If you are looking for new hearing aids in Somerset & Devon, we are the place for you!

New hearing aids Devon & Somerset

The tech inside these little wonders are amazing on so many levels. Take one of the many things they can do. They can connect to your mobile phone and you can talk wirelessly without the phone in your hand as if you were talking to a person next to you. The hearing aid is catching your voice and transmitting this to your phone via bluetooth. You can hear perfectly as your hearing aid is in your ear so you don’t have to really listen hard to get what the conversation is. It’s all done without you doing anything. This tech isn’t new, it has been around for some years, but if your hearing aids are not ”Connected” versions, then maybe when you are next due a new set of hearing aids, you can ask to be told of what’s new in this ”Connected” world.

Somerset & Devon hearing aid centres

Colin Eaton & Stephen Neal the lead audiologists at Honiton & Keynsham hearing will be happy to show you and explain all about what is new and on offer. They will also show you how you connect your new digital hearing aid with various tech such as mobile phones, iPads, and the T.V.

Make your appointment with Colin now by calling Sam on reception or use the booking form here.

Make your appointment with Stephen Neal at Keynsham by clicking here.

You can watch how ear wax removal is done by watching one of our videos here.

Ear wax removal News:

Semtech and Sonova Launch Jointly-Developed Radio System

Latest Digital hearing aids at the Honiton hearing centre, Devon

Semtech Corporation (Nasdaq: SMTC), a supplier of high-performance analog and mixed-signal semiconductors and advanced algorithms, and Sonova, a developer of hearing care solutions, announced a jointly developed advanced radio system. The ultra-small integrated circuit (IC) is said to be a main component for a new generation of hearing aids, enabling support for multiple radio protocols in the 2.4GHz band, as well as effective operation on very low power, according to the announcement.

New hearing aids Devon and Somerset

“This chip allows Sonova to move in a new direction with our hearing aids,” said Marc Secall, director, research & development, wireless, at Sonova. “The breakthrough radio technology and power management are the game changers for hearing aids. It allows them to support a number of applications that have previously not been possible in a hearing aid, all at low power consumption and low supply voltage. Possible applications span from connectivity to any Bluetooth®-enabled audio device (eg, a smartphone or television) to full duplex audio streaming between hearing aids and connectivity to wireless microphones.”

Ear wax removal Devon & Somerset

“Semtech continues to innovate and create flexible, reliable solutions for challenging applications associated with the best radio frequency connectivity at the lowest power and 0.8V supply voltage,” said Jean-Paul Bardyn, vice president of research and development of Semtech’s wireless and sensing products group. “Sonova has long been a leader for hearing devices. By implementing Semtech’s technology and enabling access to the Cloud, we believe that these devices will enrich the IoT-connected solutions which Semtech is serving with LoRa Technology.”

Source: Semtech, Sonova

Images: Semtech, Sononva

March 22, 2019/by admin

Hearing aids

Latest digital hearing aids 2019- Somerset and Devon

Looking for information on how what hearing aids would suit you or what you need? Book an appointment with the Keynsham or Honiton hearing centre and have a full spectrum hearing test done. Once the test has completed Stephen Neal at Keynsham centre or Colin Eaton at the Honiton hearing centre will sit with you and discuss the results. Once they results are know he will then go through what the different types of hearing aids (if any needed) are good for your hearing loss. There are many hearing aids available form many different manufacturers. Both the Keynsham hearing centre and the Honiton hearing centre are independent hearing centres, covering the whole of Somerset and Devon. They are not affiliated to any manufacturer so can offer you what you need rather to what we sell. We can access all the major manufactures hearing aids for you to choose from.

Ear-wax-removal.co.uk-News:

New Hear-it Report Documents Extraordinary Costs of Hearing Loss in EU

hear-it_tw_400x400

In the EU, untreated hearing loss costs 185 billion Euro–each year. –hear-it.org

A new scientific report, “Hearing Loss – Numbers and Costs”, concludes that untreated, disabling hearing loss costs 185 billion Euros (US$211 billion) in the EU each year. This represents 8,200 Euros (US$9335) each year per person with an untreated disabling hearing loss.

The detailed findings and conclusions in the report will be presented at a lunch debate at the European Parliament in Brussels, Belgium, on the March 6 in connection with the WHO World Hearing Day on the 3rd of March.

The report was carried out for the non-profit organization, hear-it AISBL, by Professor Emerita Bridget Shield with the assistance of Professor Mark Atherton at Brunel University in London. In 2006, Professor Bridget Shield compiled the first report for hear-it AISBL, “Evaluation of the Social and Economic Costs of hearing Impairment.”

How they arrived at the 185 billion Euro figure. According to the report, lower quality of life due to disabling hearing loss costs the EU 130 billion Euros (US$148 billion) each year. Lost productivity in society due to a higher unemployment among people with a disabling hearing loss costs 55 billion Euros ($63 billion) each year in the EU. In total, this is 185 billion Euros. The cost does not cover extra health care costs caused by hearing loss. A disabling hearing loss is defined by the Global Burden of Disease research group (GBD) as a hearing loss of 35 dB or greater.

In Europe as a whole—including non-EU countries—untreated, disabling hearing loss costs 216 billion Euros (US$246 billion) each year, says the researchers.

Latest digital hearing aids 2019- Somerset and Devon

The report documents that the use of hearing aids and other hearing solutions improves health and increases quality of life. It also documents that people with an untreated, disabling hearing loss are at greater risk of social isolation, depression, cognitive decline and dementia, while people who treat their hearing loss do not experience a higher risk than people without hearing loss.

There are 34.4 million people with a disabling hearing loss (35 dB or greater) in the EU. More than 22.6 million are not treated for their disabling hearing loss as only around 1 in 3 in Europe with a disabling hearing loss use hearing aids or other hearing solutions. This is more than the combined population of Austria, Finland, Ireland, and Lithuania. With a steadily aging population who live longer and with an earlier onset of hearing loss due to increased noise exposure, this growth will increase even further in the years to come, warns Hear-it.

Latest digital hearing aids 2019- Somerset and Devon

A meta study. The report, “Hearing Loss–Numbers and Costs”, is a meta study which has analyzed and compared hundreds of scientific studies and papers in the last two decades about the prevalence and the consequences of hearing loss and the use and benefits of hearing aids, according to the organization.

Kim Ruberg

“The scientific report clearly demonstrates that untreated hearing loss is a major health issue and that untreated hearing loss has a huge economic and social impact on our society,” said Secretary General Kim Ruberg, hear-it AISBL, on the organization’s website. “It also documents that checking your hearing and treating hearing loss pays, both for the individual and for society.”

Check your hearing. World Hearing Day is held by the WHO on the 3rd of March each year to raise awareness of how to prevent deafness and hearing loss and promote ear and hearing care across the world. The theme for World Hearing Day 2019 is “Check your hearing”.

Latest digital hearing aids 2019- Somerset and Devon

“If you think you might have a hearing loss, my best advice is to get your hearing checked,” says Ruberg. “You can start by checking your hearing using the WHO “Check your hearing” app, or test your hearing online at www.hear-it.org. But if you suspect that you have hearing problems my best advice is that you get a real hearing test carried out by a hearing professional,” says Ruberg.

Source: Hear-it

March 7, 2019/by admin

Earwax removal

Somerset & Devon ear wax removal

Honiton hearing centre, Devon

Somerset & Devon ear wax removal are available at the Honiton hearing centre & The Keynsham hearing centres, which caters for all types of hearing loss and ear wax removal. Colin Eaton, the lead audiologist at the Honiton hearing centre has over 15 years audiology expertise to make sure his clients get the best hearing result no matter what the hearing issues are.

Ear wax removal is available by appointment and a limited amount of out of hours appointments are available but please call Sam on reception if you require out of hours.

Somerset & Devon ear wax removal

Comprehensive hearing tests are also available. Please make sure that any ear wax issues are clear before you take the test, if you need ear wax removing prior the test please call reception and make this clear to Sam that you will need ear wax clearing first.

Please call Honiton hearing here

Keynsham hearing centre, Somerset

Keynsham hearing centre are situated between Bath and Bristol along the A4. Easy parking available. Keynsham hearing are an independent hearing centre specialising in ear wax removal and the very latest digital hearing aids supplied form at least 12 of the worlds leading hearing aid brands.

Somerset & Devon ear wax removal

Keynsham hearing also offer out of hours ear wax removal appointments. To book your appointment please call Anita on reception. Number is here

Somerset and Devon ear wax removal News:

Researchers Restore Hearing via Gene Therapy in Deaf Mouse Model

Published on February 21, 2019

In collaboration with the universities of Miami, Columbia, and San Francisco, scientists from the Institut Pasteur, Inserm, CNRS, Collège de France, Sorbonne University, and the University of Clermont Auvergne have managed to restore hearing in an adult mouse model of DFNB9 deafness, a hearing disorder that represents one of the most frequent cases of congenital genetic deafness, Institut Pasteur announced on its website. Individuals with DFNB9 deafness are profoundly deaf as they are deficient in the gene coding for otoferlin, a protein which is essential for transmitting sound information at the auditory sensory cell synapses. By carrying out an intracochlear injection of this gene in an adult DFNB9 mouse model, the scientists successfully restored auditory synapse function and hearing thresholds to a near-normal level. These findings, published in the journal PNAS, open up new avenues for future gene therapy trials in patients with DFNB9.

The left panel is a schematic representation of the human ear. Sound waves are collected by the outer ear made up of the pinna and ear canal. The middle ear, composed of the eardrum and ossicles, transmits sound waves to the inner ear, which features the cochlea – the hearing organ responsible for transmitting auditory messages to the central nervous system. The right panel shows an immunofluorescence image of the auditory sensory epithelium within an injected cochlea. The inner hair cells have been stained for otoferlin in green. Otoferlin is detected in almost all of these cells. The inset is a high magnification area showing an inner hair cell that has not been transduced. © Institut Pasteur

Over half of nonsyndromic profound congenital deafness cases have a genetic cause, and most (~80%) of these cases are due to autosomal recessive forms of deafness (DFNB). Cochlear implants are currently the only option for recovering hearing in these patients.

Somerset & Devon ear wax removal

Adeno-associated viruses (AAVs) are among the most promising vectors for therapeutic gene transfer to treat human diseases. AAV-based gene therapy is a promising therapeutic option for treating deafness but its application is limited by a potentially narrow therapeutic window. In humans, inner ear development is completed in utero and hearing becomes possible at approximately 20 weeks of gestation. In addition, genetic forms of congenital deafness are generally diagnosed during the neonatal period. Gene therapy approaches in animal models must therefore take this into account, and gene therapy efficacy must be demonstrated following a gene injection when the auditory system is already in place. In other words, therapy must reverse existing deafness. The team led by Saaïd Safieddine, a CNRS researcher in the Genetics and Physiology of Hearing Unit (Institut Pasteur/ Inserm) and coordinator of the project, used a mouse model of DFNB9, a form of human deafness that represents 2-8% of all cases of congenital genetic deafness.

DFNB9 deafness is caused by mutations in the gene coding for otoferlin, a protein that plays a key role in transmitting sound information at the inner hair cell synapses. Mutant mice deficient in otoferlin are profoundly deaf as these synapses fail to release neurotransmitters in response to sound stimulation, despite the absence of detectable sensory epithelial defects. DFNB9 mice therefore constitute an appropriate model for testing the efficacy of viral gene therapy when it is administered at a late stage. However, as AAVs have limited DNA packaging capacity (approximately 4.7 kilobase (kb)), it is difficult to use this technique for genes whose coding region (cDNA) exceeds 5 kb, such as the gene coding for otoferlin, which has a 6 kb coding region. The scientists have overcome this limitation by adapting an AAV approach known as dual AAV strategy because it uses two different recombinant vectors, one containing the 5’-end and the other the 3’-end of the otoferlin cDNA.

A single intracochlear injection of the vector pair in adult mutant mice was used to reconstruct the otoferlin coding region by recombining 5′ and 3′-end DNA segments, leading to long-term restoration of otoferlin expression in the inner hair cells, and then restored hearing.

Somerset & Devon ear wax removal

The scientists have therefore obtained initial proof of the concept of viral transfer of fragmented cDNA in the cochlea using two vectors, showing that this approach can be used to produce otoferlin and durably correct the profound deafness phenotype in mice.

The outcomes achieved by the scientists suggest that the therapeutic window for local gene transfer in patients with DFNB9 congenital deafness could be wider than thought, and offers hope of extending these findings to other forms of deafness. These results are the subject of a patent application filed.

In addition to the institutions mentioned in the first paragraph, this research was funded by the French Foundation for Medical Research, the European Union (TREAT RUSH), and the French National Research Agency (EargenCure and Lifesenses LabEx).

Original Paper: Akil O, Dyka F, Calvet C, et al. Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model. PNAS. 2019. DOI: https://doi.org/10.1073/pnas.1817537116

Source: Institut Pasteur, PNAS

Image: Institute Pasteur

February 28, 2019/by admin

Earwax removal

Cheapest ear wax removal Devon

The Cheapest ear wax removal in Devon, is at the family owned and run independent Honiton hearing centre. Covering the whole of Devon including Tiverton, Exeter Lyme bay and Sidmouth.

The Honiton hearing centre based in Honiton and is the place to book for ear wax removal and hearing tests. If you are suffering from Tinnitus Colin Eaton the lead audiologist at the Honiton hearing centre can help you with Tinnitus therapy. Local GP surgeries are no longer treating ear wax removal as part of the NHS but if you are in serious need and want to book an appointment please call Sam on reception to book your ear wax removal session. Please read the website for costs.

Watch our hearing test video here

Honiton Hearing News:

Cheapest ear wax removal in Devon

Oticon Releases Survey Highlighting Tinnitus Prevalence in the UK

Original Story by The HEARING REVIEW

For a second year, the British Tinnitus Association is hoping to raise awareness of the prevalent condition suggested to severely affect 1 in 10 of the population. People with tinnitus have a hidden condition making it difficult for others to understand what they are going through. This year’s Tinnitus Week theme will draw attention to how many people feel isolated and unable to talk to their loved ones, friends, or colleagues about their condition.

A nationally representative hearing loss survey of 2,000 UK adults commissioned by hearing aid manufacturer Oticon, reveals just how prevalent tinnitus is and highlights the importance of recognition and education of the sometimes debilitating condition, the hearing aid manufacturer announced. An alarming 21% of respondents experience tinnitus symptoms such as ringing, buzzing, or persistent noise in the ears. Among these respondents, less than half have seen a doctor or hearing care professional about their symptoms, 25% do not think that they need to, and worryingly, almost 40% are not concerned about their overall hearing health, despite nearly half reporting that they do not have good hearing.

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To underline the significance of this year’s Tinnitus Week theme of isolation, the Oticon survey reveals that the biggest effect of the widespread hearing condition is withdrawal from social situations, which 28% reported. This is followed by lack of concentration (26.4%), less alertness (25.8%), and stress (22.4%). Furthermore, two thirds experiencing tinnitus symptoms find it tiring to hear what people are saying and follow conversations in situations where there are lots of people speaking.

Alison Stone, training manager and audiologist at Oticon, says: “People with tinnitus are often more tired and can have more difficulty concentrating, especially if there is background noise in the environment. They are also more at risk of high anxiety, depression, and irritation which affects their daily quality of life a great deal. Isolation is a natural response to many of the effects of tinnitus which is why the support of friends and family is so important. We urge those with tinnitus to talk, and although there is no known cure, to explore the management options available to relieve their symptoms which could significantly minimize the impact the condition has on their life. There are trained professionals out there who understand and can help.”

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The Oticon survey results highlight that tinnitus can be experienced by anyone, with between 16% and 24% of respondents reporting symptoms in each age category. Tinnitus can indeed be experienced by anyone, as well as be temporary or permanent, constant or intermittent.

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Oticon’s Alison Stone advises: “We know that approximately 80% of those with hearing loss also have tinnitus, and 80% of those with tinnitus also have some form of hearing loss. It’s important to highlight that tinnitus can sometimes be a symptom of a treatable medical condition, so, if you are experiencing any tinnitus symptoms seek professional medical advice from your primary care doctor or an ENT consultant. Early intervention could make a difference.”

Tinnitus Week aims to increase awareness of tinnitus with a week of promotions that highlight the impact tinnitus can have on the lives of the many people affected. For more information about the condition visit: https://www.oticon.global/hearing/what-is-hearing/tinnitus

Source: Oticon, British Tinnitus Association

February 11, 2019/0 Comments/by admin